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Issue 40, 2018
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Temperature-regulated aggregation-induced emissive self-healable hydrogels for controlled drug delivery

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Abstract

Self-healable hydrogels are very attractive to bioscience and biotechnology, for use in drug loading and delivery, artificial organs, and bioswitches. In this research, thermoresponsive copolymers TPE-[P(DMA-stat-DAA)]2 containing a tetraphenylethylene (TPE) moiety and a ketone group were synthesized. The TPE unit in the middle gave the copolymer chains thermoregulated AIE properties and an LCST around body temperature. The self-healable hydrogels were prepared with a dynamic acylhydrazone bond through dihydrazide cross-linking, and the light emission properties were regulated by a thermosensitive enhanced AIE mechanism. As a result, the AIE properties were imported into the new thermoresponsive self-healable hydrogels to achieve temperature-regulated light emission properties. The in vitro cytotoxicity experiments showed that the hydrogels were biocompatible and the hydrogels showed a pH sensitive drug release profile. This kind of thermoresponsive light emission hydrogel may hold great potential for biodiagnosis, drug loading and delivery, and tissue engineering with light sensitive detection.

Graphical abstract: Temperature-regulated aggregation-induced emissive self-healable hydrogels for controlled drug delivery

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Publication details

The article was received on 20 Jul 2018, accepted on 23 Aug 2018 and first published on 31 Aug 2018


Article type: Paper
DOI: 10.1039/C8PY01064A
Citation: Polym. Chem., 2018,9, 5002-5013

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    Temperature-regulated aggregation-induced emissive self-healable hydrogels for controlled drug delivery

    X. Wang, K. Xu, H. Yao, L. Chang, Y. Wang, W. Li, Y. Zhao and J. Qin, Polym. Chem., 2018, 9, 5002
    DOI: 10.1039/C8PY01064A

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