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Full and partial hydrolysis of poly(2-oxazoline)s and subsequent post-polymerization modification of the resulting polyethylenimine (co)polymers

Abstract

The synthesis of linear polyethylenimine (L-PEI) is mostly performed via the acidic or basic hydrolysis of poly(2-alkyl-2-oxazoline)s (PAOx). Besides full hydrolysis leading to L-PEI, the partial hydrolysis of the PAOx sidechains results in PAOx-PEI copolymers having secondary amine groups in the polymer backbone. The secondary amine groups of L-PEI and PAOx-PEI can act as charge carrier for the complexation of DNA for gene therapy. Furthermore, they are also excellent chemical moieties for post-polymerization modification reactions providing straightforward acces to new PAOx (co)polymers based on a variety of PAOx, including the commercially available poly(2-ethyl-2-oxazoline) (PEtOx). Within this review, we will discuss the acidic and basic (partial) hydrolysis of PAOx as well as the corresponding mechanisms. In addition, an overview is provided of the recent literature on the post-polymerization modification of the fully hydrolyzed L-PEI and the partially hydrolyzed PAOx-PEI.

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Publication details

The article was received on 30 Jun 2018, accepted on 08 Sep 2018 and first published on 12 Sep 2018


Article type: Review Article
DOI: 10.1039/C8PY00978C
Citation: Polym. Chem., 2018, Accepted Manuscript
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    Full and partial hydrolysis of poly(2-oxazoline)s and subsequent post-polymerization modification of the resulting polyethylenimine (co)polymers

    M. Mees and R. Hoogenboom, Polym. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8PY00978C

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