Jump to main content
Jump to site search

Issue 40, 2018
Previous Article Next Article

Full and partial hydrolysis of poly(2-oxazoline)s and the subsequent post-polymerization modification of the resulting polyethylenimine (co)polymers

Author affiliations

Abstract

The synthesis of linear polyethylenimine (L-PEI) is mostly performed via the acidic or basic hydrolysis of poly(2-alkyl-2-oxazoline)s (PAOx). Besides full hydrolysis leading to L-PEI, the partial hydrolysis of the PAOx sidechains results in PAOx-PEI copolymers having secondary amine groups in the polymer backbone. The secondary amine groups of L-PEI and PAOx-PEI can act as charge carriers for the complexation of DNA for gene therapy. Furthermore, they are also excellent chemical moieties for post-polymerization modification reactions providing straightforward access to new PAOx (co)polymers based on a variety of PAOx, including the commercially available poly(2-ethyl-2-oxazoline) (PEtOx). Within this review, we will discuss the acidic and basic (partial) hydrolysis of PAOx as well as the corresponding mechanisms. In addition, an overview of the recent literature on the post-polymerization modification of the fully hydrolyzed L-PEI and the partially hydrolyzed PAOx-PEI is provided.

Graphical abstract: Full and partial hydrolysis of poly(2-oxazoline)s and the subsequent post-polymerization modification of the resulting polyethylenimine (co)polymers

Back to tab navigation

Publication details

The article was received on 30 Jun 2018, accepted on 08 Sep 2018 and first published on 12 Sep 2018


Article type: Review Article
DOI: 10.1039/C8PY00978C
Citation: Polym. Chem., 2018,9, 4968-4978
  •   Request permissions

    Full and partial hydrolysis of poly(2-oxazoline)s and the subsequent post-polymerization modification of the resulting polyethylenimine (co)polymers

    M. A. Mees and R. Hoogenboom, Polym. Chem., 2018, 9, 4968
    DOI: 10.1039/C8PY00978C

Search articles by author

Spotlight

Advertisements