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Issue 25, 2018
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Cyclodextrin-based host–guest supramolecular hydrogel and its application in biomedical fields

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Abstract

The cyclodextrin (CD) based host–guest inclusion complexation between cyclodextrins (CDs) and guest moieties has inspired the fabrication of novel supramolecular hydrogels for biomedical applications. From a topology of view, this article reviews the recent developments of two kinds of CD-based supramolecular hydrogels and their applications in biomedical fields respectively. On one hand, supramolecular hydrogels derived from CD-based poly(pseudo)rotaxanes generally displayed thixotropic and reversible properties and have been extensively developed as injectable drug delivery systems. On the other hand, supramolecular hydrogels based on the host–guest interaction between CDs and small guest moieties generally exhibited stimuli-responsive behaviors, typically the release of therapeutic agents. The development of CD-based supramolecular hydrogels provides a new platform for the design of novel biomaterials.

Graphical abstract: Cyclodextrin-based host–guest supramolecular hydrogel and its application in biomedical fields

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Article information


Submitted
16 May 2018
Accepted
07 Jun 2018
First published
08 Jun 2018

Polym. Chem., 2018,9, 3436-3449
Article type
Review Article

Cyclodextrin-based host–guest supramolecular hydrogel and its application in biomedical fields

G. Liu, Q. Yuan, G. Hollett, W. Zhao, Y. Kang and J. Wu, Polym. Chem., 2018, 9, 3436
DOI: 10.1039/C8PY00730F

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