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Issue 25, 2018
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Aspect-ratio-dependent interaction of molecular polymer brushes and multicellular tumour spheroids

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Abstract

Polymer nanoparticles based on molecular polymer brushes allow precise and independent tailoring of nanoparticle characteristics. This enables the synthesis of soft hydrophilic polymer particles with matching composition and surface chemistry where only the aspect-ratio is varied. PEGylated brush nanoparticles revealed that brush nanorods exhibit higher association and penetration into multicellular tumour spheroids compared to their spherical or filamentous counterparts.

Graphical abstract: Aspect-ratio-dependent interaction of molecular polymer brushes and multicellular tumour spheroids

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Supplementary files

Article information


Submitted
08 May 2018
Accepted
07 Jun 2018
First published
08 Jun 2018

Polym. Chem., 2018,9, 3461-3465
Article type
Communication
Author version available

Aspect-ratio-dependent interaction of molecular polymer brushes and multicellular tumour spheroids

M. Müllner, K. Yang, A. Kaur and E. J. New, Polym. Chem., 2018, 9, 3461
DOI: 10.1039/C8PY00703A

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