Issue 4, 2018

Reporting pH-sensitive drug release via unpaired spin fluorescence silencing

Abstract

We pioneer an approach for the visualization of pH-controlled molecular release of a fluorescent drug from a nitroxide polymer which combined yields a profluorescent system. A methacrylate-based terpolymer, bearing water-solubilizing triethylene-glycol chains, unpaired spins in the form of nitroxide and hydrazone-bound doxorubicin was synthesized to explore the possibilities of release quantification from profluorescent assemblies. Critically, we establish the fluorescence-silencing effect of polymer-bound nitroxides on covalently attached fluorophores and the overall accessibility of such constructs. The facile approach towards a functional assembly shown here provides an easy-to-assemble construct for complex delivery architectures towards applications in theranostics.

Graphical abstract: Reporting pH-sensitive drug release via unpaired spin fluorescence silencing

Supplementary files

Article information

Article type
Paper
Submitted
20 Nov 2017
Accepted
20 Dec 2017
First published
10 Jan 2018

Polym. Chem., 2018,9, 499-505

Reporting pH-sensitive drug release via unpaired spin fluorescence silencing

M. Eing, B. Olshausen, K. E. Fairfull-Smith, U. Schepers, C. Barner-Kowollik and J. P. Blinco, Polym. Chem., 2018, 9, 499 DOI: 10.1039/C7PY01942D

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