Issue 10, 2018

In vitro and in vivo studies of a chlorin-based carbon nanocarrier with photodynamic therapy features

Abstract

Carbonaceous materials have long been developed to utilize “nano-spaces” and numerous guest species could be encapsulated. A remarkable fluorescence difference has been observed after newly designed pyropheophorbide-a-appended carbon nanohorns were incorporated in a cellular medium and confocal microscopy was employed for the determination of the intracellular localization. Our study supported the role of carbon nanohorns as carriers of photodynamic therapy (PDT) agents and their heating behavior was discussed. We have developed a theranostic platform based on photosensitizer-conjugated carbon nanostructures and this system has been applied in an animal model. In addition, a negligible toxicity of CNH-Pyro was found in body weight experiments and histopathological examination of the major organs.

Graphical abstract: In vitro and in vivo studies of a chlorin-based carbon nanocarrier with photodynamic therapy features

Supplementary files

Article information

Article type
Paper
Submitted
06 Jul 2018
Accepted
30 Jul 2018
First published
06 Aug 2018

Photochem. Photobiol. Sci., 2018,17, 1329-1336

In vitro and in vivo studies of a chlorin-based carbon nanocarrier with photodynamic therapy features

Z. Zhou, Y. Zheng, C. C. Zhang, J. Gao, Y. Tang and Q. Wang, Photochem. Photobiol. Sci., 2018, 17, 1329 DOI: 10.1039/C8PP00287H

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