Issue 1, 2019

Lipid vesicle-loaded meso-substituted chlorins of high in vitro antimicrobial photodynamic activity

Abstract

Photodynamic inactivation potential against bacteria of four chlorin derivatives with phenyl or fluorophenyl substituents was evaluated. The quantum yield values of singlet oxygen formation were in the range of 0.16–0.86. Compounds were characterized by high quantum yields of fluorescence (0.15–0.44) and moderate photostability in DMF solutions. Irradiation of chlorins in DMSO resulted in their phototransformation and then photodecomposition. Photodynamic inactivation of bacteria was performed after the compounds had been loaded into lipid vesicles. The following log reductions of growth values were obtained: Enterococcus faecalis >5.44; Staphylococcus aureus 2.74–5.34; Escherichia coli 0.01–2.14. No activity of meso-substituted chlorins was noticed against Pseudomonas aeruginosa and fungi Candida albicans and Trichophyton mentagrophytes.

Graphical abstract: Lipid vesicle-loaded meso-substituted chlorins of high in vitro antimicrobial photodynamic activity

Supplementary files

Article information

Article type
Paper
Submitted
19 Jun 2018
Accepted
25 Oct 2018
First published
31 Oct 2018

Photochem. Photobiol. Sci., 2019,18, 213-223

Lipid vesicle-loaded meso-substituted chlorins of high in vitro antimicrobial photodynamic activity

L. Sobotta, D. Ziental, J. Sniechowska, J. Dlugaszewska and M. J. Potrzebowski, Photochem. Photobiol. Sci., 2019, 18, 213 DOI: 10.1039/C8PP00258D

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