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Lipid vesicle-loaded meso-substituted chlorins of high in vitro antimicrobial photodynamic activity

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Abstract

Photodynamic inactivation potential against bacteria of four chlorin derivatives with phenyl or fluorophenyl substituents was evaluated. The quantum yield values of singlet oxygen formation were in the range of 0.16–0.86. Compounds were characterized by high quantum yields of fluorescence (0.15–0.44) and moderate photostability in DMF solutions. Irradiation of chlorins in DMSO resulted in their phototransformation and then photodecomposition. Photodynamic inactivation of bacteria was performed after the compounds had been loaded into lipid vesicles. The following log reductions of growth values were obtained: Enterococcus faecalis >5.44; Staphylococcus aureus 2.74–5.34; Escherichia coli 0.01–2.14. No activity of meso-substituted chlorins was noticed against Pseudomonas aeruginosa and fungi Candida albicans and Trichophyton mentagrophytes.

Graphical abstract: Lipid vesicle-loaded meso-substituted chlorins of high in vitro antimicrobial photodynamic activity

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Publication details

The article was received on 19 Jun 2018, accepted on 25 Oct 2018 and first published on 31 Oct 2018


Article type: Paper
DOI: 10.1039/C8PP00258D
Citation: Photochem. Photobiol. Sci., 2019, Advance Article
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    Lipid vesicle-loaded meso-substituted chlorins of high in vitro antimicrobial photodynamic activity

    L. Sobotta, D. Ziental, J. Sniechowska, J. Dlugaszewska and M. J. Potrzebowski, Photochem. Photobiol. Sci., 2019, Advance Article , DOI: 10.1039/C8PP00258D

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