Jump to main content
Jump to site search

Issue 8, 2018
Previous Article Next Article

Irradiation with 310 nm and 340 nm ultraviolet light-emitting-diodes can improve atopic dermatitis-like skin lesions in NC/Nga mice

Author affiliations

Abstract

Ultraviolet (UV) light produces an immunomodulatory effect on the skin and is widely used for the treatment of chronic inflammatory skin diseases. UV light emitting diodes (UV-LEDs) are a new and promising source of UV radiation. However, their mechanism of action remains largely unknown. In this study, we tested the safety and effectiveness of UV-LED irradiation for the treatment of atopic dermatitis (AD) in an NC/Nga mouse model. Mice were divided into seven groups of eight mice each. Application of Dermatophagoides farinae (Df) extract ointment for four weeks induced AD-like skin lesions. Subsequently, the mice were exposed to UV-LEDs, narrow band UVB, or UVA irradiation three times per week. We assessed the immunosuppressive effects of 310 nm (50 mJ cm−2) and 340 nm (5 J cm−2) UV-LED irradiation. Histological analyses using hematoxylin–eosin, toluidine blue, and immunohistochemical staining were performed. In addition, the serum levels of IgE, inflammatory cytokines and chemokines were measured using enzyme-linked immunosorbent assays (ELISAs). UV-LED irradiation significantly alleviated AD-like skin symptoms, including edema, erythema, dryness, and itching, by modulating Th1 and Th2 responses, transepidermal water loss (TEWL), and scratching behavior in NC/Nga mice. These results suggest that UV-LEDs can improve the treatment of inflammatory skin diseases.

Graphical abstract: Irradiation with 310 nm and 340 nm ultraviolet light-emitting-diodes can improve atopic dermatitis-like skin lesions in NC/Nga mice

Back to tab navigation

Supplementary files

Publication details

The article was received on 10 Feb 2018, accepted on 03 Jul 2018 and first published on 13 Jul 2018


Article type: Paper
DOI: 10.1039/C8PP00063H
Citation: Photochem. Photobiol. Sci., 2018,17, 1127-1135
  •   Request permissions

    Irradiation with 310 nm and 340 nm ultraviolet light-emitting-diodes can improve atopic dermatitis-like skin lesions in NC/Nga mice

    T. Kwon, J. H. Kim, J. Hong, J. Seok, J. M. Kim, D. Bak, M. Choi, S. K. Mun, C. W. Kim and B. J. Kim, Photochem. Photobiol. Sci., 2018, 17, 1127
    DOI: 10.1039/C8PP00063H

Search articles by author

Spotlight

Advertisements