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Issue 12, 2018
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Drug and chemical induced photosensitivity from a clinical perspective

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Abstract

Drug photosensitivity is a relatively common occurrence and a range of mechanisms may be involved. Some of these mechanisms will be discussed, including the most common, that of drug phototoxicity. Different types of photosensitivity are addressed with respect to clinical presentation, mechanisms and additionally the contribution to our understanding through clinically directed investigations and regulatory requirements. Repeated controlled therapeutic use of drug phototoxicity, with psoralen-UVA (PUVA) photochemotherapy and photodynamic therapy (PDT) will also be discussed. Finally, the potential for drug-induced photocarcinogenesis will also be covered.

Graphical abstract: Drug and chemical induced photosensitivity from a clinical perspective

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Article information


Submitted
12 Jan 2018
Accepted
09 Sep 2018
First published
10 Sep 2018

Photochem. Photobiol. Sci., 2018,17, 1885-1903
Article type
Perspective

Drug and chemical induced photosensitivity from a clinical perspective

S. Ibbotson, Photochem. Photobiol. Sci., 2018, 17, 1885
DOI: 10.1039/C8PP00011E

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