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Issue 11, 2018
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The good, the bad, and the ugly – controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy

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Abstract

Singlet oxygen, although integral to photodynamic therapy, is notoriously uncontrollable, suffers from poor selectivity and has fast decomposition rates in biological media. Across the scientific community, there is a conscious effort to refine singlet oxygen interactions and initiate selective and controlled release to produce a consistent and reproducible therapeutic effect in target tissue. This perspective aims to provide an insight into the contemporary design principles behind photosensitizers and drug delivery systems that depend on a singlet oxygen response or controlled release. The discussion will be accompanied by in vitro and in vivo examples, in an attempt to highlight advancements in the field and future prospects for the more widespread application of photodynamic therapy.

Graphical abstract: The good, the bad, and the ugly – controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy

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Article information


Submitted
11 Jan 2018
Accepted
16 Mar 2018
First published
20 Mar 2018

Photochem. Photobiol. Sci., 2018,17, 1490-1514
Article type
Perspective

The good, the bad, and the ugly – controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy

S. Callaghan and M. O. Senge, Photochem. Photobiol. Sci., 2018, 17, 1490
DOI: 10.1039/C8PP00008E

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