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Low wintertime pre-diagnostic vitamin D status is associated with an increased risk of internal malignancies in kidney transplant recipients

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Abstract

Low serum 25-hydroxyvitamin D (25OHD) concentrations have been associated with increased cancer risk, but the relative importance of seasonality, i.e. high summer concentrations versus low winter concentrations, is unclear. We investigated this issue in a high risk group: kidney transplant recipients with known increased risk of cancer and low vitamin D statuses. We examined the relationship between registered concentrations of 25OHD binned by quarter and subsequent risk of internal malignancy or cutaneous squamous cell carcinoma in 1112 kidney transplant recipients. Hazard ratios for internal malignancies were significantly increased with lower pre-diagnostic 25OHD concentrations in the first quarter of the year (January–March); a 1.4 fold increase (95%CI 1.1;1.7) per 10 nmol L−1 decrease in 25OHD. Except for women in April–June (1.3 (1.01;1.7) per 10 nmol L−1 decrease) pre-diagnostic 25OHD concentrations in the other quarters were not statistically significantly associated with internal malignancies. Higher 25OHD concentrations tended to be associated with the development of cutaneous squamous cell carcinomas, independent of the time of the year. Our study indicates that low wintertime 25OHD concentrations are associated with an increased risk of internal malignancies and that transplant recipients may benefit from wintertime vitamin D supplementation. Our findings need further corroboration, but suggest that the lowest concentrations of vitamin D, which occur in winter, are important for the risk of internal malignancies.

Graphical abstract: Low wintertime pre-diagnostic vitamin D status is associated with an increased risk of internal malignancies in kidney transplant recipients

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Publication details

The article was received on 30 Oct 2017, accepted on 28 Oct 2018 and first published on 06 Nov 2018


Article type: Paper
DOI: 10.1039/C7PP00404D
Citation: Photochem. Photobiol. Sci., 2018, Advance Article
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    Low wintertime pre-diagnostic vitamin D status is associated with an increased risk of internal malignancies in kidney transplant recipients

    F. R. de Gruijl, R. Wolterbeek, S. Pavel, J. W. de Fijter, N. A. T. Hamdy and J. N. Bouwes Bavinck, Photochem. Photobiol. Sci., 2018, Advance Article , DOI: 10.1039/C7PP00404D

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