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Issue 48, 2018
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Aldehydes can switch the chemoselectivity of electrophiles in protein labeling

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Abstract

We show that the chemoselectivity of an electrophile in protein labeling can be promiscuous. An aldehyde enables switching of chemoselectivity of an epoxide and a sulfonate ester along with an enhanced rate of reaction. The chemical technology renders single-site installation of diverse probes on a protein and delivers analytically pure tagged proteins.

Graphical abstract: Aldehydes can switch the chemoselectivity of electrophiles in protein labeling

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Publication details

The article was received on 20 Nov 2018, accepted on 28 Nov 2018 and first published on 28 Nov 2018


Article type: Communication
DOI: 10.1039/C8OB02897D
Citation: Org. Biomol. Chem., 2018,16, 9377-9381
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    Aldehydes can switch the chemoselectivity of electrophiles in protein labeling

    S. R. Adusumalli, D. G. Rawale and V. Rai, Org. Biomol. Chem., 2018, 16, 9377
    DOI: 10.1039/C8OB02897D

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