Ring-closing metathesis of unprotected peptides in water†
Ring-closing metathesis (RCM) is an attractive reaction for the preparation of artificially designed peptides. Until now, RCM has been used for fully or partially protected peptides. Herein, the first RCM of unprotected peptides in water was achieved using a water-soluble Ru catalyst.
- This article is part of the themed collection: Chemical biology in OBC