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Issue 48, 2018
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Ring-closing metathesis of unprotected peptides in water

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Abstract

Ring-closing metathesis (RCM) is an attractive reaction for the preparation of artificially designed peptides. Until now, RCM has been used for fully or partially protected peptides. Herein, the first RCM of unprotected peptides in water was achieved using a water-soluble Ru catalyst.

Graphical abstract: Ring-closing metathesis of unprotected peptides in water

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Publication details

The article was received on 08 Nov 2018, accepted on 24 Nov 2018 and first published on 27 Nov 2018


Article type: Communication
DOI: 10.1039/C8OB02778A
Citation: Org. Biomol. Chem., 2018,16, 9364-9367
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    Ring-closing metathesis of unprotected peptides in water

    S. Masuda, S. Tsuda and T. Yoshiya, Org. Biomol. Chem., 2018, 16, 9364
    DOI: 10.1039/C8OB02778A

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