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Issue 48, 2018
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Ring-closing metathesis of unprotected peptides in water

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Abstract

Ring-closing metathesis (RCM) is an attractive reaction for the preparation of artificially designed peptides. Until now, RCM has been used for fully or partially protected peptides. Herein, the first RCM of unprotected peptides in water was achieved using a water-soluble Ru catalyst.

Graphical abstract: Ring-closing metathesis of unprotected peptides in water

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Article information


Submitted
08 Nov 2018
Accepted
24 Nov 2018
First published
27 Nov 2018

Org. Biomol. Chem., 2018,16, 9364-9367
Article type
Communication

Ring-closing metathesis of unprotected peptides in water

S. Masuda, S. Tsuda and T. Yoshiya, Org. Biomol. Chem., 2018, 16, 9364
DOI: 10.1039/C8OB02778A

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