Jia-Yu Zhou, Chun Ma, Yi-Zhu Zhang, Qiong Wu and Feng Shi
Org. Biomol. Chem., 2018,16, 9382-9389
DOI:
10.1039/C8OB02776E,
Paper
The title reaction has been established, which offers a useful method for the construction of dihydrocoumarin frameworks in generally good chemical yields (up to 99%) and high diastereoselectivities (up to >95 : 5 dr). This reaction represents a good example of [4 + 2] cyclizations of para-quinone methide derivatives with electron-rich reaction partners under catalyst-free conditions.
![Graphical abstract: Catalyst-free [4 + 2] cyclization of para-quinone methide derivatives with homophthalic anhydrides](/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=C8OB02776E "Graphical abstract")
