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A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam

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Abstract

A simple route to enantiomerically pure (S)-2-aminobutyramide – the chiral component of the anti-epileptic drugs Levetiracetam and Brivaracetam has been developed. This approach is based on the rational design and application of a Viedma ripening process. The practical potential of the process is demonstrated on a large scale.

Graphical abstract: A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam

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Publication details

The article was received on 26 Oct 2018, accepted on 05 Nov 2018 and first published on 05 Nov 2018


Article type: Communication
DOI: 10.1039/C8OB02660B
Citation: Org. Biomol. Chem., 2018, Advance Article
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    A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam

    I. Baglai, M. Leeman, R. M. Kellogg and W. L. Noorduin, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB02660B

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