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Issue 46, 2018
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Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery

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Abstract

We demonstrate a proof of principle for a new approach in the development of a drug delivery system. A positively charged prodrug (phenol) can form a stable inclusion complex with CB[7], which enables more efficient delivery of the prodrug. After photochemical transformation (photoactivation) inside the complex, an active drug quinone methide (QM) is formed and released from the complex, since it is a neutral molecule and forms a less stable complex with CB[7].

Graphical abstract: Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery

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Supplementary files

Article information


Submitted
20 Oct 2018
Accepted
05 Nov 2018
First published
05 Nov 2018

Org. Biomol. Chem., 2018,16, 8908-8912
Article type
Communication

Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery

Đ. Škalamera, M. Matković, L. Uzelac, M. Kralj, K. Mlinarić-Majerski, C. Bohne and N. Basarić, Org. Biomol. Chem., 2018, 16, 8908
DOI: 10.1039/C8OB02605J

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