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Issue 45, 2018
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Rh-Catalyzed aminative dearomatization of 2-naphthols

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A direct aminative dearomatization of 2-naphthols was achieved. In the presence of 1 mol% Rh2(esp)2 and 3 equivalents of O-(2,4-dinitrophenyl)hydroxylamine (DPH) as readily available aminating reagents, the reactions of 2-naphthols afforded unprotected α-amino-β-naphthalenones in good yields under mild reaction conditions. The conditions were compatible with gram-scale reaction, and the product could undergo diverse transformations.

Graphical abstract: Rh-Catalyzed aminative dearomatization of 2-naphthols

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Supplementary files

Article information

19 Oct 2018
30 Oct 2018
First published
31 Oct 2018

Org. Biomol. Chem., 2018,16, 8700-8703
Article type

Rh-Catalyzed aminative dearomatization of 2-naphthols

J. Yi, H. Tu and S. You, Org. Biomol. Chem., 2018, 16, 8700
DOI: 10.1039/C8OB02592D

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