Jump to main content
Jump to site search

Issue 44, 2018
Previous Article Next Article

Multimerization of DAB-1 onto Au GNPs affords new potent and selective N-acetylgalactosamine-6-sulfatase (GALNS) inhibitors

Author affiliations

Abstract

Gold glyconanoparticles (Au GNPs) decorated with the natural iminosugar DAB-1 at different densities are reported. These new multivalent iminosugar architectures strongly and selectively inhibit N-acetylgalactosamine-6-sulfatase (GALNS), whose deficiency is connected to the lysosomal storage disease Morquio A. The combination of the dendrimeric technique with the synthetic strategy employed for Au GNP preparation allowed the enhancement of the multivalent presentation of the iminosugar onto the surface of gold nanoparticles, which resulted in the best GALNS inhibitor reported to date (IC50 = 520 nM).

Graphical abstract: Multimerization of DAB-1 onto Au GNPs affords new potent and selective N-acetylgalactosamine-6-sulfatase (GALNS) inhibitors

Back to tab navigation

Supplementary files

Publication details

The article was received on 18 Oct 2018, accepted on 22 Oct 2018 and first published on 22 Oct 2018


Article type: Paper
DOI: 10.1039/C8OB02587H
Citation: Org. Biomol. Chem., 2018,16, 8604-8612
  •   Request permissions

    Multimerization of DAB-1 onto Au GNPs affords new potent and selective N-acetylgalactosamine-6-sulfatase (GALNS) inhibitors

    C. Matassini, C. Vanni, A. Goti, A. Morrone, M. Marradi and F. Cardona, Org. Biomol. Chem., 2018, 16, 8604
    DOI: 10.1039/C8OB02587H

Search articles by author

Spotlight

Advertisements