Issue 44, 2018
From the journal:

Organic & Biomolecular Chemistry

Electrolysis promoted reductive amination of electron-deficient aldehydes/ketones: a green route to the racemic clopidogrel†

Qianyun Zhang,ab   Wen Zhu,a   Jinzhong Yao,*a   Xiaofang Lic  and  Hongwei Zhou ORCID logo *a  

* Corresponding authors

a College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, People's Republic of China
E-mail: jzyao@zju.edu.cn, zhouhw@zju.edu.cn

b Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

c School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201, People's Republic of China

Abstract

An electrocatalytic reductive amination of electron-deficient aldehydes/ketones was developed, which could be used in the synthesis of functionalized tertiary amines and large scale preparation of racemic clopidogrel. A plausible mechanism involving an iminium cation intermediate was proposed.

Graphical abstract: Electrolysis promoted reductive amination of electron-deficient aldehydes/ketones: a green route to the racemic clopidogrel

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Article information

DOI
https://doi.org/10.1039/C8OB02500B
Article type
Communication
Submitted
09 Oct 2018
Accepted
22 Oct 2018
First published
22 Oct 2018

Org. Biomol. Chem., 2018,16, 8462-8466

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Electrolysis promoted reductive amination of electron-deficient aldehydes/ketones: a green route to the racemic clopidogrel

Q. Zhang, W. Zhu, J. Yao, X. Li and H. Zhou, Org. Biomol. Chem., 2018, 16, 8462 DOI: 10.1039/C8OB02500B

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