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Issue 44, 2018
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Electrolysis promoted reductive amination of electron-deficient aldehydes/ketones: a green route to the racemic clopidogrel

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Abstract

An electrocatalytic reductive amination of electron-deficient aldehydes/ketones was developed, which could be used in the synthesis of functionalized tertiary amines and large scale preparation of racemic clopidogrel. A plausible mechanism involving an iminium cation intermediate was proposed.

Graphical abstract: Electrolysis promoted reductive amination of electron-deficient aldehydes/ketones: a green route to the racemic clopidogrel

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Publication details

The article was received on 09 Oct 2018, accepted on 22 Oct 2018 and first published on 22 Oct 2018


Article type: Communication
DOI: 10.1039/C8OB02500B
Org. Biomol. Chem., 2018,16, 8462-8466

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    Electrolysis promoted reductive amination of electron-deficient aldehydes/ketones: a green route to the racemic clopidogrel

    Q. Zhang, W. Zhu, J. Yao, X. Li and H. Zhou, Org. Biomol. Chem., 2018, 16, 8462
    DOI: 10.1039/C8OB02500B

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