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Multicomponent dipolar cycloadditions: efficient synthesis of polycyclic fused pyrrolizidines via azomethine ylides

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Abstract

An efficient multicomponent dipolar cycloaddition for the synthesis of polycyclic fused pyrrolizidines was developed using N-aromatic zwitterions, aldehydes, and amino acids. The developed reactions proceed through azomethine ylides generated in situ from the decarboxylated reactions of aldehydes and amino acids followed by the [3 + 2] cycloaddition of N-aromatic zwitterions under mild reaction conditions.

Graphical abstract: Multicomponent dipolar cycloadditions: efficient synthesis of polycyclic fused pyrrolizidines via azomethine ylides

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Publication details

The article was received on 03 Oct 2018, accepted on 09 Nov 2018 and first published on 13 Nov 2018


Article type: Communication
DOI: 10.1039/C8OB02463D
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Multicomponent dipolar cycloadditions: efficient synthesis of polycyclic fused pyrrolizidines via azomethine ylides

    S. Samala, D. H. Ryu, C. E. Song and E. J. Yoo, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB02463D

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