Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 45, 2018
Previous Article Next Article

Iron-catalyzed cascade addition/cyclization of 2-biphenyl isocyanides with toluenes: a highly efficient approach to 6-benzylated phenanthridines

Author affiliations

Abstract

A highly efficient Fe-catalyzed cascade addition/cyclization of 2-biphenyl isocyanides with toluenes for the synthesis of 6-benzylated phenanthridines has been reported. Di-tert-butyl peroxide (DTBP) was employed as both a radical initiator and an oxidant. The procedure tolerates various functional groups, providing the corresponding products in moderate to good yields. The proposed mechanism involves the cascade addition of benzyl radicals to the isocyanides and the following radical aromatic cyclization.

Graphical abstract: Iron-catalyzed cascade addition/cyclization of 2-biphenyl isocyanides with toluenes: a highly efficient approach to 6-benzylated phenanthridines

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 Oct 2018, accepted on 31 Oct 2018 and first published on 02 Nov 2018


Article type: Paper
DOI: 10.1039/C8OB02462F
Citation: Org. Biomol. Chem., 2018,16, 8837-8844

  •   Request permissions

    Iron-catalyzed cascade addition/cyclization of 2-biphenyl isocyanides with toluenes: a highly efficient approach to 6-benzylated phenanthridines

    L. Wang, W. Xiong, Y. Peng and Q. Ding, Org. Biomol. Chem., 2018, 16, 8837
    DOI: 10.1039/C8OB02462F

Search articles by author

Spotlight

Advertisements