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Asymmetric hydrogenation of imines with chiral alkene-derived boron Lewis acids

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Abstract

With the aim of developing easily accessible chiral Lewis acids for asymmetric hydrogenation, a variety of binaphthyl-based chiral alkenes were prepared in one step from the corresponding diols. Using the in situ generated chiral boron Lewis acids through the hydroboration of chiral alkenes with Piers’ borane, metal-free asymmetric hydrogenations of imines were realized to furnish the desired amine products in high yields with up to 89% ee.

Graphical abstract: Asymmetric hydrogenation of imines with chiral alkene-derived boron Lewis acids

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Publication details

The article was received on 01 Oct 2018, accepted on 25 Oct 2018 and first published on 25 Oct 2018


Article type: Communication
DOI: 10.1039/C8OB02446D
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Asymmetric hydrogenation of imines with chiral alkene-derived boron Lewis acids

    X. Liu, T. Liu, W. Meng and H. Du, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB02446D

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