Jump to main content
Jump to site search


Intermolecular alkene difunctionalizations for the synthesis of saturated heterocycles

Author affiliations

Abstract

Saturated heterocycles are important structural motifs in a range of pharmaceuticals and agrochemicals. As a result of their importance, syntheses of these molecules have been extensively investigated. Despite the progress in this area, the most adopted strategies are still often characterized with inefficiency or relying on functionalizations with specialized precursors and pre-existing cores. This review highlights a dynamic synthetic strategy for the direct synthesis of saturated heterocycles from intermolecular alkene difunctionalizations. These coupling processes are highly modular, and therefore, offer perhaps the most convenient means to prepare diverse heterocyclic structures in compound libraries for bioactivity evoluations.

Graphical abstract: Intermolecular alkene difunctionalizations for the synthesis of saturated heterocycles

Back to tab navigation

Publication details

The article was received on 01 Oct 2018, accepted on 13 Nov 2018 and first published on 13 Nov 2018


Article type: Review Article
DOI: 10.1039/C8OB02443J
Citation: Org. Biomol. Chem., 2018, Advance Article
  •   Request permissions

    Intermolecular alkene difunctionalizations for the synthesis of saturated heterocycles

    N. Kaur, F. Wu, N. Alom, J. P. Ariyarathna, S. J. Saluga and W. Li, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB02443J

Search articles by author

Spotlight

Advertisements