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Issue 44, 2018
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Base-catalyzed selective esterification of alcohols with unactivated esters

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Abstract

A practical and efficient base-catalyzed esterification has been developed for the facile synthesis of a broad range of esters from simple alcohols with unactivated tert-butyl esters. This protocol could be conducted at mild conditions, providing esters in high to excellent yields with good functional tolerance. Mechanistic studies provided evidence of an exchange of the tert-butyl alkoxide metal with the alcohol, producing a new alkoxide to participate in the transesterification reaction.

Graphical abstract: Base-catalyzed selective esterification of alcohols with unactivated esters

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Publication details

The article was received on 27 Sep 2018, accepted on 17 Oct 2018 and first published on 17 Oct 2018


Article type: Communication
DOI: 10.1039/C8OB02411A
Citation: Org. Biomol. Chem., 2018,16, 8467-8471
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    Base-catalyzed selective esterification of alcohols with unactivated esters

    C. Zhang, G. Zhang, S. Luo, C. Wang and H. Li, Org. Biomol. Chem., 2018, 16, 8467
    DOI: 10.1039/C8OB02411A

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