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Catalyst-free 1:2 annulation of quinolines with trifluoroacetylacetylenes: a one-pot access to oxazinoquinolines decorated by trifluoromethyl, acetylene and ketone functions

Abstract

Metal- and solvent-free reaction of quinolines with two molecules of aryltrifluoroacetylacetylenes afforded 3-arylethynyl-3-trifluoromethyl-1,3-oxazinoquinolines in up to 92% yields. The formation of zwitterionic intermediate at the first step triggered multistep domino reaction.

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Publication details

The article was received on 25 Sep 2018, accepted on 11 Oct 2018 and first published on 12 Oct 2018


Article type: Communication
DOI: 10.1039/C8OB02379D
Citation: Org. Biomol. Chem., 2018, Accepted Manuscript
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    Catalyst-free 1:2 annulation of quinolines with trifluoroacetylacetylenes: a one-pot access to oxazinoquinolines decorated by trifluoromethyl, acetylene and ketone functions

    B. Trofimov, K. Belyaeva, L. Nikitina, A. Afonin, A. V. Vashchenko, V. Muzalevskiy and V. Nenajdenko, Org. Biomol. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8OB02379D

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