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Issue 42, 2018
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Regioselective [3 + 2]-annulation of hydrazonyl chlorides with 1,3-dicarbonyl compounds for assembling of polysubstituted pyrazoles

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Abstract

A facile approach to polysubstituted pyrazoles from hydrazonyl chlorides and 1,3-dicarbonyl compounds has been developed. In the presence of DMAP combined with Et3N, hydrazonyl chlorides reacted with N-phenyl-3-oxobutanamides smoothly to afford a series of polysubstituted pyrazoles in 67–98% yields via the [3 + 2]-cycloaddition.

Graphical abstract: Regioselective [3 + 2]-annulation of hydrazonyl chlorides with 1,3-dicarbonyl compounds for assembling of polysubstituted pyrazoles

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Publication details

The article was received on 21 Sep 2018, accepted on 11 Oct 2018 and first published on 11 Oct 2018


Article type: Communication
DOI: 10.1039/C8OB02352B
Citation: Org. Biomol. Chem., 2018,16, 7811-7814
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    Regioselective [3 + 2]-annulation of hydrazonyl chlorides with 1,3-dicarbonyl compounds for assembling of polysubstituted pyrazoles

    K. Liu, X. Shang, Y. Cheng, X. Chang, P. Li and W. Li, Org. Biomol. Chem., 2018, 16, 7811
    DOI: 10.1039/C8OB02352B

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