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Issue 46, 2018
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Donor- and acceptor-enynals/enynones

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Enynals and enynones have emerged as focal substrates in organic synthesis in view of their structure diversity, high reactivity and intermediate variety. Transition metal- or Lewis acid-promoted protocols starting from enynals/enynones could provide efficient and direct access to functionalized homo- or heterocyclic compounds. In consideration of the different electronic properties of substituents on the alkyne group of enynals/enynones, they are classified into two kinds in this review, namely donor-enynals/enynones with non-electron-withdrawing substituents and acceptor-enynals/enynones with electron-withdrawing moieties. Herein we mainly introduced three kinds of transformations based on benzo-fused donor- and acceptor-enynals/enynones, including their reactions with alkenes, alkynes, and H2O, respectively.

Graphical abstract: Donor- and acceptor-enynals/enynones

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The article was received on 21 Sep 2018, accepted on 30 Oct 2018 and first published on 30 Oct 2018

Article type: Review Article
DOI: 10.1039/C8OB02348D
Org. Biomol. Chem., 2018,16, 8884-8898

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    Donor- and acceptor-enynals/enynones

    L. Chen, Z. Liu and S. Zhu, Org. Biomol. Chem., 2018, 16, 8884
    DOI: 10.1039/C8OB02348D

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