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Iodine Monobromide Catalysed Regioselective Synthesis of 3-Arylquinolines from α-Aminoacetophenones and trans-β-Nitrostyrenes

Abstract

A simple and an efficient method for regioselective synthesis of 3-arylquinolines is described from α-aminoacetophenones and trans-β-nitrostyrene using 20 mol % iodine monobromide as a catalyst in acetonitrile solvent at 80 °C. The present method involves tandem reaction of α-aminoacetophenones and trans-β-nitrostyrene, formation of two new C-C bonds and cleavage of one C-C bond in a single step. The salient features of the protocol are metal- and oxidant-free reaction conditions, broad substrates scope, and good yields.

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Publication details

The article was received on 20 Sep 2018, accepted on 04 Dec 2018 and first published on 05 Dec 2018


Article type: Paper
DOI: 10.1039/C8OB02333F
Citation: Org. Biomol. Chem., 2018, Accepted Manuscript
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    Iodine Monobromide Catalysed Regioselective Synthesis of 3-Arylquinolines from α-Aminoacetophenones and trans-β-Nitrostyrenes

    R. Gattu, S. Mondal, S. Ali and A. T. Khan, Org. Biomol. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8OB02333F

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