Jump to main content
Jump to site search


Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects

Author affiliations

Abstract

Classical steroids are long-known privileged leads in drug discovery. Their rearranged counterparts, though, have so far received less attention, although recent isolation and biological testing programmes have revealed a plethora of molecular entities that are both structurally intriguing, as well as biologically relevant. This review will highlight those natural products, and focus on ergostane-derived seco- and abeo-steroids. Their isolation, structure elucidation, and biological properties are reported. A special emphasis of this review lies in their respective (and typically proposed) biosyntheses, to help guide future bio-inspired synthetic attempts.

Graphical abstract: Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects

Back to tab navigation

Publication details

The article was received on 19 Sep 2018, accepted on 18 Oct 2018 and first published on 24 Oct 2018


Article type: Review Article
DOI: 10.1039/C8OB02325E
Citation: Org. Biomol. Chem., 2018, Advance Article
  •   Request permissions

    Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects

    F. L. Duecker, F. Reuß and P. Heretsch, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB02325E

Search articles by author

Spotlight

Advertisements