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Issue 44, 2018
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Direct defluorinative amidation–hydrolysis reaction of gem-difluoroalkenes with N,N-dimethylformamide, and primary and secondary amines

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Abstract

A novel and efficient method for the synthesis of arylacetamides by the reactions of gem-difluoroalkenes with N,N-dialkylformamides, and primary and secondary amines with the assistance of KOtBu and water was developed.

Graphical abstract: Direct defluorinative amidation–hydrolysis reaction of gem-difluoroalkenes with N,N-dimethylformamide, and primary and secondary amines

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Publication details

The article was received on 19 Sep 2018, accepted on 17 Oct 2018 and first published on 18 Oct 2018


Article type: Paper
DOI: 10.1039/C8OB02322K
Citation: Org. Biomol. Chem., 2018,16, 8546-8552
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    Direct defluorinative amidation–hydrolysis reaction of gem-difluoroalkenes with N,N-dimethylformamide, and primary and secondary amines

    B. Wang, X. Zhao, Q. Liu and S. Cao, Org. Biomol. Chem., 2018, 16, 8546
    DOI: 10.1039/C8OB02322K

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