Direct defluorinative amidation–hydrolysis reaction of gem-difluoroalkenes with N,N-dimethylformamide, and primary and secondary amines

Biyun Wang; Xianghu Zhao; Qingyun Liu; Song Cao

doi:10.1039/C8OB02322K

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Direct defluorinative amidation–hydrolysis reaction of gem-difluoroalkenes with N,N-dimethylformamide, and primary and secondary amines†

Biyun Wang,^a Xianghu Zhao,^a Qingyun Liu^a and Song Cao

*^a

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* Corresponding authors

^a Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology (ECUST), Shanghai 200237, China
E-mail: scao@ecust.edu.cn

Abstract

A novel and efficient method for the synthesis of arylacetamides by the reactions of gem-difluoroalkenes with N,N-dialkylformamides, and primary and secondary amines with the assistance of KOtBu and water was developed.

This article is part of the themed collection: Synthetic methodology in OBC

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Article information

DOI: https://doi.org/10.1039/C8OB02322K
Article type: Paper
Submitted: 19 Sep 2018
Accepted: 17 Oct 2018
First published: 18 Oct 2018

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Org. Biomol. Chem., 2018,16, 8546-8552

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Direct defluorinative amidation–hydrolysis reaction of gem-difluoroalkenes with N,N-dimethylformamide, and primary and secondary amines

B. Wang, X. Zhao, Q. Liu and S. Cao, Org. Biomol. Chem., 2018, 16, 8546 DOI: 10.1039/C8OB02322K

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Organic & Biomolecular Chemistry

Direct defluorinative amidation–hydrolysis reaction of gem-difluoroalkenes with N,N-dimethylformamide, and primary and secondary amines†

Abstract

Supplementary files

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Direct defluorinative amidation–hydrolysis reaction of gem-difluoroalkenes with N,N-dimethylformamide, and primary and secondary amines

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