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Synthesis of the core structure of phalarine

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Abstract

The core skeleton of phalarine was rapidly synthesised through novel palladium-catalysed dearomative spirocyclisation and a palladium-catalysed Wacker-carbonylative cyclisation cascade. The two key steps allowed for the efficient construction of a tricyclic propeller skeleton bearing contiguous tetrasubstituted carbon centres, within 3 steps from a topologically planar precursor.

Graphical abstract: Synthesis of the core structure of phalarine

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Publication details

The article was received on 19 Sep 2018, accepted on 29 Sep 2018 and first published on 01 Oct 2018


Article type: Communication
DOI: 10.1039/C8OB02320D
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Synthesis of the core structure of phalarine

    K. Douki, J. Shimokawa and M. Kitamura, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB02320D

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