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Direct (het)arylation of tetrahydroisoquinolines via a metal and oxidant free C(sp3)–H functionalization enabled three component reaction

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Abstract

An unprecedented method for the direct arylation and heteroarylation of tetrahydroisoquinolines under metal and oxidant free conditions is reported. The arylation reactions occurred via a C(sp3)–H functionalization enabled three component condensation of tetrahydroisoquinolines, 9-fluorenone imine, and arenes without involving a pre-functionalization/pre-derivatization step. A wide range of arenes and heteroarenes participated in the reaction to provide structurally diverse arylated tetrahydroisoquinolines with good to excellent yields.

Graphical abstract: Direct (het)arylation of tetrahydroisoquinolines via a metal and oxidant free C(sp3)–H functionalization enabled three component reaction

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Publication details

The article was received on 18 Sep 2018, accepted on 24 Nov 2018 and first published on 26 Nov 2018


Article type: Communication
DOI: 10.1039/C8OB02309C
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Direct (het)arylation of tetrahydroisoquinolines via a metal and oxidant free C(sp3)–H functionalization enabled three component reaction

    S. Haldar and C. K. Jana, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB02309C

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