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Issue 45, 2018
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Synthesis of chiral seven-membered β-substituted lactams via Rh-catalyzed asymmetric hydrogenation

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Abstract

Rh/bisphosphine-thiourea ligand (ZhaoPhos)-catalyzed asymmetric hydrogenation of seven-membered β-substituted α,β-unsaturated lactams was successfully developed to prepare various chiral seven-membered β-substituted lactams with good to excellent results (up to >99% conversion, 99% yield, and >99% ee).

Graphical abstract: Synthesis of chiral seven-membered β-substituted lactams via Rh-catalyzed asymmetric hydrogenation

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Publication details

The article was received on 10 Sep 2018, accepted on 24 Oct 2018 and first published on 08 Nov 2018


Article type: Paper
DOI: 10.1039/C8OB02231C
Citation: Org. Biomol. Chem., 2018,16, 8819-8823

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    Synthesis of chiral seven-membered β-substituted lactams via Rh-catalyzed asymmetric hydrogenation

    Y. Huang, P. Li, X. Dong and X. Zhang, Org. Biomol. Chem., 2018, 16, 8819
    DOI: 10.1039/C8OB02231C

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