Issue 45, 2018

Synthesis of chiral seven-membered β-substituted lactams via Rh-catalyzed asymmetric hydrogenation

Abstract

Rh/bisphosphine-thiourea ligand (ZhaoPhos)-catalyzed asymmetric hydrogenation of seven-membered β-substituted α,β-unsaturated lactams was successfully developed to prepare various chiral seven-membered β-substituted lactams with good to excellent results (up to >99% conversion, 99% yield, and >99% ee).

Graphical abstract: Synthesis of chiral seven-membered β-substituted lactams via Rh-catalyzed asymmetric hydrogenation

Supplementary files

Article information

Article type
Paper
Submitted
10 Sep 2018
Accepted
24 Oct 2018
First published
08 Nov 2018

Org. Biomol. Chem., 2018,16, 8819-8823

Synthesis of chiral seven-membered β-substituted lactams via Rh-catalyzed asymmetric hydrogenation

Y. Huang, P. Li, X. Dong and X. Zhang, Org. Biomol. Chem., 2018, 16, 8819 DOI: 10.1039/C8OB02231C

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