Yi Huang, Pan Li, Xiu-Qin Dong and Xumu Zhang
Org. Biomol. Chem., 2018,16, 8819-8823
DOI:
10.1039/C8OB02231C,
Paper
Rh/bisphosphine-thiourea ligand (ZhaoPhos)-catalyzed asymmetric hydrogenation of seven-membered β-substituted α,β-unsaturated lactams was successfully developed to prepare various chiral seven-membered β-substituted lactams with good to excellent results (up to >99% conversion, 99% yield, and >99% ee).