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Rh/bisphosphine-thiourea ligand (ZhaoPhos)-catalyzed asymmetric hydrogenation of seven-membered β-substituted α,β-unsaturated lactams was successfully developed to prepare various chiral seven-membered β-substituted lactams with good to excellent results (up to >99% conversion, 99% yield, and >99% ee).

Graphical abstract: Synthesis of chiral seven-membered β-substituted lactams via Rh-catalyzed asymmetric hydrogenation

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