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Issue 41, 2018
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Iodine-mediated regio- and stereoselective iodothiocyanation of alkynes in aqueous ethanol

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Abstract

Iodothiocyanation of alkynes with ammonium thiocyanate (NH4SCN) and molecular iodine (I2) has been demonstrated in aqueous ethanol, which enables efficient synthesis of a series of functional β-iodo vinylthiocyanates in good to excellent yields under mild reaction conditions without the need for any protection.

Graphical abstract: Iodine-mediated regio- and stereoselective iodothiocyanation of alkynes in aqueous ethanol

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Publication details

The article was received on 08 Sep 2018, accepted on 26 Sep 2018 and first published on 27 Sep 2018


Article type: Communication
DOI: 10.1039/C8OB02216J
Citation: Org. Biomol. Chem., 2018,16, 7557-7560
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    Iodine-mediated regio- and stereoselective iodothiocyanation of alkynes in aqueous ethanol

    X. Zeng and L. Chen, Org. Biomol. Chem., 2018, 16, 7557
    DOI: 10.1039/C8OB02216J

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