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Issue 42, 2018

Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes

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Abstract

A Cu(I)-catalysed addition and cyclisation sequence has been developed for the synthesis of (E)-alkylidene pyrrolinone derivatives. The reactions incorporate simple α-keto amides and alkynes as substrates, and employ a commercially available Cu(I) catalyst. The process tolerates good variation of both starting materials, and delivers the desired pyrrolinones in good yields, with high levels of stereocontrol.

Graphical abstract: Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes

Supplementary files

Article information


Submitted
06 Sep 2018
Accepted
12 Oct 2018
First published
17 Oct 2018

This article is Open Access

Org. Biomol. Chem., 2018,16, 7797-7800
Article type
Communication

Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes

Q. W. Tan, P. Chovatia and M. C. Willis, Org. Biomol. Chem., 2018, 16, 7797 DOI: 10.1039/C8OB02205D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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