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Issue 42, 2018
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Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes

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Abstract

A Cu(I)-catalysed addition and cyclisation sequence has been developed for the synthesis of (E)-alkylidene pyrrolinone derivatives. The reactions incorporate simple α-keto amides and alkynes as substrates, and employ a commercially available Cu(I) catalyst. The process tolerates good variation of both starting materials, and delivers the desired pyrrolinones in good yields, with high levels of stereocontrol.

Graphical abstract: Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes

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Publication details

The article was received on 06 Sep 2018, accepted on 12 Oct 2018 and first published on 17 Oct 2018


Article type: Communication
DOI: 10.1039/C8OB02205D
Citation: Org. Biomol. Chem., 2018,16, 7797-7800
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    Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes

    Q. W. Tan, P. Chovatia and M. C. Willis, Org. Biomol. Chem., 2018, 16, 7797
    DOI: 10.1039/C8OB02205D

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