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Synthesis of benzimidazoles by CuI-catalyzed three-component reaction of 2-haloaniline, ammonia and aldehyde in water

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Abstract

An efficient copper-catalyzed three-component reaction of 2-haloaniline, ammonia and aldehyde for the synthesis of benzimidazoles with 1,10-phenanthroline as the ligand has been developed. A variety of substituted benzimidazole derivatives can be obtained in yields up to 95%.

Graphical abstract: Synthesis of benzimidazoles by CuI-catalyzed three-component reaction of 2-haloaniline, ammonia and aldehyde in water

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Publication details

The article was received on 04 Sep 2018, accepted on 09 Oct 2018 and first published on 10 Oct 2018


Article type: Paper
DOI: 10.1039/C8OB02172D
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Synthesis of benzimidazoles by CuI-catalyzed three-component reaction of 2-haloaniline, ammonia and aldehyde in water

    F. Ke, P. Zhang, C. Lin, X. Lin, J. Xu and X. Zhou, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB02172D

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