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Issue 44, 2018
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Azobenzene-based small molecular photoswitches for protein modulation

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Abstract

Molecular photoswitches are a class of chemical structures that can readily isomerize between distinct geometries upon irradiation with light. Molecular photoswitches are utilized to control protein structure and function with temporal and spatial precision. In this review, we summarize the recent progress in the development of azobenzene-based molecular photoswitches and their applications in the photocontrol of protein structure and function. For clarity of discussion, we divide the known photoswitchable proteins into different categories: protein motifs, ion channels, receptors, and enzymes. Basic approaches and considerations for the structure-guided design of photoswitchable ligands are discussed. The applications and limitations of current photoswitches are also discussed.

Graphical abstract: Azobenzene-based small molecular photoswitches for protein modulation

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Publication details

The article was received on 01 Sep 2018, accepted on 17 Oct 2018 and first published on 30 Oct 2018


Article type: Review Article
DOI: 10.1039/C8OB02157K
Citation: Org. Biomol. Chem., 2018,16, 8434-8445
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    Azobenzene-based small molecular photoswitches for protein modulation

    M. Zhu and H. Zhou, Org. Biomol. Chem., 2018, 16, 8434
    DOI: 10.1039/C8OB02157K

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