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Issue 37, 2018
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Dimericursones A and B: two unprecedented hexacyclic dimeric diterpenoids from the root barks of Jatropha curcas

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Abstract

Dimericursones A and B (1 and 2), two unprecedented hexacyclic dimeric diterpenoids, were obtained from the root barks of Jatropha curcas. Their structures were elucidated by extensive spectroscopic analysis, electronic circular dichroism calculations, and single-crystal X-ray diffraction. Dimericursone B (2) showed significant inhibition on nitric oxide production of lipopolysaccharide-induced RAW264.7 macrophages with IC50 values of 5.65 μM.

Graphical abstract: Dimericursones A and B: two unprecedented hexacyclic dimeric diterpenoids from the root barks of Jatropha curcas

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Publication details

The article was received on 26 Aug 2018, accepted on 11 Sep 2018 and first published on 11 Sep 2018


Article type: Paper
DOI: 10.1039/C8OB02082E
Citation: Org. Biomol. Chem., 2018,16, 8305-8310
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    Dimericursones A and B: two unprecedented hexacyclic dimeric diterpenoids from the root barks of Jatropha curcas

    J. Liu, Y. Xu, Q. Xiao, J. Huang, J. Ma, C. Lian, M. Huang, Z. Du and C. Wang, Org. Biomol. Chem., 2018, 16, 8305
    DOI: 10.1039/C8OB02082E

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