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Issue 7, 2019
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Highly regioselective α-alkylation of α,β,γ,δ-unsaturated aldehydes

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Abstract

The first α-alkylation of α,β,γ,δ-unsaturated aldehydes is achieved under mild reaction conditions. Several α,β,γ,δ-unsaturated aldehydes and diarylcarbinols are successfully tested for the synthesis of MBH-type α-alkylated products with an excellent regioselectivity. Simple pyrrolidine is efficiently used as a catalyst to achieve a perfect E/Z selectivity of the α-alkylated products.

Graphical abstract: Highly regioselective α-alkylation of α,β,γ,δ-unsaturated aldehydes

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Article information


Submitted
22 Aug 2018
Accepted
05 Sep 2018
First published
05 Sep 2018

Org. Biomol. Chem., 2019,17, 1714-1717
Article type
Communication

Highly regioselective α-alkylation of α,β,γ,δ-unsaturated aldehydes

V. M. D. Padmaja, S. Jangra and C. Appayee, Org. Biomol. Chem., 2019, 17, 1714
DOI: 10.1039/C8OB02059K

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