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Issue 39, 2018
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Efficient construction of tetrahydroquinolines via fluorinated alcohol mediated cascade [1,5]-hydride transfer/cyclization

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Abstract

An environmentally benign cascade redox-neutral process was developed for the efficient construction of pharmaceutically significant spirocyclic tetrahydro-quinolines via a 3-step cascade Knoevenagel condensation/[1,5]-hydride transfer/cyclization, which features green and additive-free conditions, wide substrate scope, and high step- and atom-economy.

Graphical abstract: Efficient construction of tetrahydroquinolines via fluorinated alcohol mediated cascade [1,5]-hydride transfer/cyclization

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Publication details

The article was received on 17 Aug 2018, accepted on 14 Sep 2018 and first published on 15 Sep 2018


Article type: Communication
DOI: 10.1039/C8OB02012D
Citation: Org. Biomol. Chem., 2018,16, 7109-7114
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    Efficient construction of tetrahydroquinolines via fluorinated alcohol mediated cascade [1,5]-hydride transfer/cyclization

    C. Chen, L. Xu, L. Wang and S. Li, Org. Biomol. Chem., 2018, 16, 7109
    DOI: 10.1039/C8OB02012D

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