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Issue 38, 2018
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Synthesis of α-amino ketones through aminations of umpoled enolates

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Abstract

An efficient synthesis of α-amino ketones is developed using the umpolung strategy. Umpoled enolates such as N-alkenoxypyridinium salts react smoothly with diverse amines to give α-amino ketones via an SN2′ pathway. This umpolung strategy overcomes the drawbacks of traditional methods such as the need for prefunctionalized ketone derivatives. Our method also offers good chemical yields and high functional group tolerance.

Graphical abstract: Synthesis of α-amino ketones through aminations of umpoled enolates

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Publication details

The article was received on 16 Aug 2018, accepted on 07 Sep 2018 and first published on 07 Sep 2018


Article type: Paper
DOI: 10.1039/C8OB02004C
Citation: Org. Biomol. Chem., 2018,16, 6918-6922
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    Synthesis of α-amino ketones through aminations of umpoled enolates

    X. Xia, B. Chen, X. Zeng and B. Xu, Org. Biomol. Chem., 2018, 16, 6918
    DOI: 10.1039/C8OB02004C

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