Jump to main content
Jump to site search

Issue 41, 2018
Previous Article Next Article

Tandem radical cyclization of N-methacryloyl benzamides with CBr4 to construct brominated isoquinolinediones

Author affiliations

Abstract

A simple cumene (isopropylbenzene, IPB) promoted auto-oxidation involved tandem radical cyclization of N-methacryloyl benzamides using stable and easy-to-handle CBr4 as the bromine source is described. This strategy provides an efficient and practical approach for the synthesis of bromine containing isoquinolinediones. This method also presents a new way to generate bromine radicals using a mild auto-oxidation pathway.

Graphical abstract: Tandem radical cyclization of N-methacryloyl benzamides with CBr4 to construct brominated isoquinolinediones

Back to tab navigation

Supplementary files

Publication details

The article was received on 11 Aug 2018, accepted on 01 Oct 2018 and first published on 02 Oct 2018


Article type: Paper
DOI: 10.1039/C8OB01964A
Citation: Org. Biomol. Chem., 2018,16, 7748-7752
  •   Request permissions

    Tandem radical cyclization of N-methacryloyl benzamides with CBr4 to construct brominated isoquinolinediones

    S. Huang, P. Niu, Y. Su, D. Hu and C. Huo, Org. Biomol. Chem., 2018, 16, 7748
    DOI: 10.1039/C8OB01964A

Search articles by author

Spotlight

Advertisements