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Immune responses against Lewis Y tumor-associated carbohydrate antigen displayed densely on self-assembling nanocarriers

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Abstract

Immune responses against Lewis y (LY) displayed on nanocarriers at different surface densities were studied. The high surface density of LY was obtained by the A2B-type amphiphilic polypeptides having LY at the two terminals [LY-poly(sarcosine)2-b-(L- or D-Leu-Aib)6]. The equimolar mixture of these two amphiphilic polypeptides formed interdigitated planar sheet-like molecular assemblies densely displaying LY (G4). G4 seemed to induce the anti-LY IgM upon immunization to BALB/c mice by only a single administration. However, the amount of anti-LY IgM produced was moderate and significantly less than that induced by two administrations of the other molecular assembly (G1) with the average surface density of LY at a 1/4 of that of G4. Further, the anti-LY IgM produced after two administrations of G4 lowered the avidity more than after one administration.

Graphical abstract: Immune responses against Lewis Y tumor-associated carbohydrate antigen displayed densely on self-assembling nanocarriers

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Publication details

The article was received on 10 Aug 2018, accepted on 02 Oct 2018 and first published on 03 Oct 2018


Article type: Paper
DOI: 10.1039/C8OB01955J
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Immune responses against Lewis Y tumor-associated carbohydrate antigen displayed densely on self-assembling nanocarriers

    Y. Yamazaki, Y. Nambu, M. Ohmae, M. Sugai and S. Kimura, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB01955J

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