Issue 43, 2018

Manganese catalyzed N-alkylation of anilines with alcohols: ligand enabled selectivity

Abstract

Ligand enabled Earth-abundant manganese catalyzed N-alkylation of amines with alcohols via a hydrogen auto-transfer strategy is reported. The choice of the ligand plays a significant role in the alcohol reactivity (aliphatic or aromatic) toward N-alkylation reactions.

Graphical abstract: Manganese catalyzed N-alkylation of anilines with alcohols: ligand enabled selectivity

Supplementary files

Article information

Article type
Paper
Submitted
03 Aug 2018
Accepted
08 Oct 2018
First published
08 Oct 2018

Org. Biomol. Chem., 2018,16, 8175-8180

Manganese catalyzed N-alkylation of anilines with alcohols: ligand enabled selectivity

V. G. Landge, A. Mondal, V. Kumar, A. Nandakumar and E. Balaraman, Org. Biomol. Chem., 2018, 16, 8175 DOI: 10.1039/C8OB01886C

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