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Issue 37, 2018
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Glycodendron–rhenium complexes as luminescent probes for lectin sensing

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Abstract

The design, synthesis and characterization of novel glycoconjugate luminescent probes based on dinuclear rhenium(I) complexes are reported. A multivalent platform bearing different carbohydrate moieties (Glc, Gal and Man) was used to target carbohydrate-binding proteins (lectins), exploiting the unique photophysical characteristics of a Re(I) luminophore for protein sensing. Our results show that these glycoconjugates, non-luminescent in aqueous medium, are able to specifically bind different lectins (ConA and PNA) with a consequent enhancement of emission intensity. These findings suggest the use of Re(I)-based glycoconjugates as switch-on luminescent probe tools in biological applications.

Graphical abstract: Glycodendron–rhenium complexes as luminescent probes for lectin sensing

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Publication details

The article was received on 30 Jul 2018, accepted on 05 Sep 2018 and first published on 05 Sep 2018


Article type: Paper
DOI: 10.1039/C8OB01838C
Citation: Org. Biomol. Chem., 2018,16, 8413-8419
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    Glycodendron–rhenium complexes as luminescent probes for lectin sensing

    A. Palmioli, M. Panigati and A. Bernardi, Org. Biomol. Chem., 2018, 16, 8413
    DOI: 10.1039/C8OB01838C

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