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Organocatalytic asymmetric syntheses of 3-fluorooxindoles containing vicinal fluoroamine motifs

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Abstract

An organocatalytic Mannich reaction of 3-fluorooxindoles has been developed. Using a commercially available cinchona alkaloid catalyst, a wide range of 3-fluorooxindoles was successfully reacted with N-sulfonyl aldimines to give biologically important 3-fluorooxindoles containing vicinal fluoroamine motifs with high efficiency and good enantioselectivity. This protocol uses readily available reactants and cheap organocatalysts, and it is operationally simple.

Graphical abstract: Organocatalytic asymmetric syntheses of 3-fluorooxindoles containing vicinal fluoroamine motifs

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Publication details

The article was received on 25 Jul 2018, accepted on 06 Nov 2018 and first published on 07 Nov 2018


Article type: Paper
DOI: 10.1039/C8OB01786G
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Organocatalytic asymmetric syntheses of 3-fluorooxindoles containing vicinal fluoroamine motifs

    B. Zheng, L. Chen, J. Zhao, J. Ji, Z. Qiu, X. Ren and Y. Li, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB01786G

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